Data ID: AD00103
Species: Human
Region: Prefrontal cortex
Condition: Disease
Braak stage: "5-6"
Sex: Female
Age: 75-90+ years
Number of cells: 5679
Number of identified cell types: 7
Title: Single-cell Transcriptomic Analysis of Alzheimer's Disease
Methodology: Single-nucleus RNA-seq
Protocol: 10x Genomics
Public Data ID: syn18485175
Pubmed: 31042697
DOI: 10.1038/s41586-019-1195-2
Statement: The results published here are in whole or in part based on data obtained from the AD Knowledge Portal (https://adknowledgeportal.org). Samples for this study were provided by the Rush Alzheimer' Disease Center, Rush University Medical Center, Chicago. Data collection was supported through funding by NIA grants P30AG10161, R01AG15819, R01AG17917, R01AG30146, R01AG36836, U01AG32984, U01AG46152, the Illinois Department of Public Health, and the Translational Genomics Research Institute.
Cell type & subcluster:
Total cells in the plot: 5679
Gene expression
Point size:
Please enter a gene symbol.
Note: The MAST package were used to calculate DEGs on normalized gene expression data (parameter: log2FC > 0.25, adj.p-value < 0.05).
Group:
Cell type of interest:
Log2 fold-change cutoff:
Adjusted p-value cutoff:
Total genes returned from query without filtering: 3268
Total genes in the table after filtering: 1467
| Gene name | Log fold-change | Pct.1 | Pct.2 | Adjusted p-value |
|---|---|---|---|---|
| GPR98 | 2.33453 | 0.904 | 0.137 | 7.23e-276 |
| SLC1A2 | 2.24716 | 0.851 | 0.15 | 2.96e-225 |
| AQP4 | 2.10245 | 0.712 | 0.035 | 1.06e-206 |
| GPC5 | 2.01335 | 0.933 | 0.233 | 4.75e-198 |
| PITPNC1 | 1.95478 | 0.909 | 0.215 | 3.14e-188 |
| RYR3 | 2.0448 | 0.827 | 0.129 | 3.45e-181 |
| RNF219-AS1 | 2.1608 | 0.663 | 0.024 | 3.63e-180 |
| GJA1 | 2.04526 | 0.611 | 0.007 | 4.31e-177 |
| RANBP3L | 1.96302 | 0.615 | 0.023 | 4.57e-165 |
| LINC00499 | 2.04782 | 0.577 | 0.009 | 2.02e-163 |
| COL5A3 | 1.77972 | 0.577 | 0.049 | 6.82e-160 |
| RFX4 | 1.81806 | 0.587 | 0.059 | 3.09e-159 |
| DTNA | 1.5362 | 0.947 | 0.415 | 1.56e-156 |
| TPD52L1 | 1.95006 | 0.683 | 0.044 | 2.00e-156 |
| ATP1A2 | 1.93211 | 0.688 | 0.062 | 3.99e-153 |