Details - ssREAD

General information

Overview

Data ID: AD00110

Species: Human

Region: Prefrontal cortex

Condition: Disease

Braak stage: 1, 4 - 5

Sex: Female

Age: 77-90+ years

Related datasets

AD00101 | AD00106 | AD00107 | AD00108 | AD00109 | AD00110 |

Dataset information

Number of cells: 15300

Number of identified cell types: 7

Dataset source

Title: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease

Methodology: Single-nucleus RNA-seq

Protocol: 10x Genomics

Public Data ID: syn21125841

Pubmed: 31932797

DOI: 10.1038/s41591-019-0695-9

Cell clustering

Cell type & subcluster:

Total cells in the plot: 15300

Gene expression

Point size:

4

Please enter a gene symbol.

Differential expression (DE) / Gene set enrichment

Note: The MAST package were used to calculate DEGs on normalized gene expression data (parameter: log2FC > 0.25, adj.p-value < 0.05).

Group:

Find differentially expressed genes in each cell type by comparing it to all of the others.

Cell type of interest:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6

10^-5

10^-4

10^-3

0.01

0.05

0.1

1

DE direction:

All

UP

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Search

Total genes returned from query without filtering: 2204

Total genes in the table after filtering: 233

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SLC1A2	2.87611	0.891	0.278	0.00e+0
ATP1A2	2.50032	0.845	0.153	0.00e+0
ADGRV1	2.47457	0.713	0.093	0.00e+0
AQP4	2.46597	0.756	0.108	0.00e+0
GJA1	2.34641	0.686	0.06	0.00e+0
GFAP	2.29681	0.848	0.129	0.00e+0
GLUL	2.10638	0.857	0.32	0.00e+0
COL5A3	2.04411	0.597	0.07	0.00e+0
AHNAK	2.03573	0.705	0.047	0.00e+0
ATP1B2	2.00043	0.71	0.159	0.00e+0
SLC25A18	1.92909	0.64	0.052	0.00e+0
CST3	1.92787	0.813	0.254	0.00e+0
TPD52L1	1.89208	0.612	0.075	0.00e+0
HIF3A	1.83805	0.666	0.068	0.00e+0
SLC14A1	1.79017	0.521	0.013	0.00e+0