Details - ssREAD

General information

Overview

Data ID: AD00201

Species: Human

Region: Entorhinal Cortex

Condition: Control

Braak stage: 0

Sex: Male

Age: mean age 77.6, range 67.3-91 years; 50-91 years

Related datasets

AD00201 | AD00202 | AD00203 | AD00204 | AD00205 | AD00206 | AD00801 | AD00802 | AD00803 | AD06401 | AD06402 |

Dataset information

Number of cells: 29993

Number of identified cell types: 6

Dataset source 1

Title: A Single-Cell Atlas of Entorhinal Cortex From Individuals With Alzheimer's Disease Reveals Cell-Type-Specific Gene Expression Regulation

Methodology: Single-nucleus RNA-seq

Protocol: DroNc-seq

Public Data ID: GSE138852

Pubmed: 31768052

DOI: 10.1038/s41593-019-0539-4

Dataset source 2

Title: Molecular characterization of selectively vulnerable neurons in Alzheimer’s Disease

Methodology: Single-nucleus RNA-seq

Protocol: 10x Genomics

Public Data ID: GSE147528

Pubmed: 33432193

DOI: 10.1101/2020.04.04.025825

Cell clustering

Cell type & subcluster:

Total cells in the plot: 29993

Gene expression

Point size:

4

Please enter a gene symbol.

Differential expression (DE) / Gene set enrichment

Note: The MAST package were used to calculate DEGs on normalized gene expression data (parameter: log2FC > 0.25, adj.p-value < 0.05).

Group:

Find differentially expressed genes in each cell type by comparing it to all of the others.

Cell type of interest:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6

10^-5

10^-4

10^-3

0.01

0.05

0.1

1

DE direction:

All

UP

Down

Search

Total genes returned from query without filtering: 1703

Total genes in the table after filtering: 230

Sort by
SLC1A2	3.098	0.834	0.106	0.00e+0
ADGRV1	2.86821	0.797	0.059	0.00e+0
RNF219-AS1	2.76788	0.704	0.024	0.00e+0
SLC1A3	2.54543	0.85	0.091	0.00e+0
APOE	2.50028	0.722	0.069	0.00e+0
GPC5	2.28437	0.816	0.163	0.00e+0
MT2A	2.2798	0.582	0.043	0.00e+0
FGFR3	2.2429	0.605	0.029	0.00e+0
NKAIN3	2.11467	0.679	0.093	0.00e+0
PITPNC1	2.10437	0.793	0.126	0.00e+0
DTNA	2.08441	0.827	0.171	0.00e+0
CST3	2.08133	0.617	0.073	0.00e+0
EMX2	2.04195	0.463	0.007	0.00e+0
GFAP	2.04057	0.418	0.04	0.00e+0
GJA1	1.99003	0.429	0.014	0.00e+0