Details - ssREAD

General information

Overview

Data ID: AD00205

Species: Human

Region: Entorhinal Cortex

Condition: Disease

Braak stage: 2

Sex: Male

Age: 50-91 years

Related datasets

AD00201 | AD00205 | AD00206 | AD00801 | AD00802 | AD00803 | AD06401 | AD06402 |

Dataset information

Number of cells: 19282

Number of identified cell types: 6

Dataset source

Title: Molecular characterization of selectively vulnerable neurons in Alzheimer’s Disease

Methodology: Single-nucleus RNA-seq

Protocol: 10x Genomics

Public Data ID: GSE147528

Pubmed: 33432193

DOI: 10.1101/2020.04.04.025825

Cell clustering

Cell type & subcluster:

Total cells in the plot: 19282

Gene expression

Point size:

4

Please enter a gene symbol.

Differential expression (DE) / Gene set enrichment

Note: The MAST package were used to calculate DEGs on normalized gene expression data (parameter: log2FC > 0.25, adj.p-value < 0.05).

Group:

Find differentially expressed genes in each cell type by comparing it to all of the others.

Cell type of interest:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6

10^-5

10^-4

10^-3

0.01

0.05

0.1

1

DE direction:

All

UP

Down

Search

Total genes returned from query without filtering: 1243

Total genes in the table after filtering: 47

Sort by
ADGRV1	2.45364	0.611	0.063	0.00e+0
SLC1A2	2.43446	0.716	0.13	0.00e+0
RNF219-AS1	2.27422	0.502	0.036	0.00e+0
GPC5	2.12119	0.691	0.129	0.00e+0
GJA1	2.02879	0.383	0.017	0.00e+0
GFAP	2.00614	0.509	0.073	0.00e+0
FGFR3	1.91817	0.428	0.042	0.00e+0
CLU	1.86437	0.682	0.196	0.00e+0
SDC4	1.83865	0.298	0.013	0.00e+0
PITPNC1	1.80587	0.583	0.134	0.00e+0
APOE	1.78373	0.534	0.084	0.00e+0
ATP1A2	1.78373	0.454	0.056	0.00e+0
AQP4	1.76791	0.328	0.015	0.00e+0
EMX2	1.71731	0.256	0.006	0.00e+0
GLIS3	1.71545	0.366	0.036	0.00e+0