Summary
Publication

Title: Neuroinflammatory astrocyte subtypes in the mouse brain

Authors: Philip Hasel, Indigo V. L. Rose, Jessica S. Sadick, Rachel D. Kim & Shane A. Liddelow

Date published: 8/19/21

Date added: 5/1/22

Journal: Nature Neuroscience

DOI: 10.1038/s41593-021-00905-6

Protocol: 10x Genomics Visium

Data source: GSE165098

Study design

Species: mouse

Number of samples: 6

Region: Whole brain

Figure: Astrocytes undergo a fast inflammatory transition that drastically changes over time.

Spot-level data

Select sample:

Current selection:

ssREAD sample ID: ST00801

Sample raw name: GSM5026144

Total spots in the plot: 582

Clusters to plot:

Image opacity:

0.4

Point opacity:

1
13612111268575123140246020406080100120140
Number of Spots

Gene expression

Please enter a gene symbol.

Spatially variable genes

Sample:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6
10^-5
10^-4
10^-3
0.01
0.05
0.1
1
Foldchange direction:
Gene nameLog fold-changetarget_domainAdjusted p-valuein_group_fractionout_group_fractionin_out_group_ratioin_group_mean_expout_group_mean_exp
Differential expression (DE) / Gene set enrichment

Sample:

Note: The MAST package were used to calculate DEGs on normalized gene expression data (parameter: log2FC > 0.25, adj.p-value < 0.05).

Group:

Cluster:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6
10^-5
10^-4
10^-3
0.01
0.05
0.1
1
DE direction:
Gene nameLog fold-changePct.1Pct.2Adjusted p-value
ssREAD is developed by BMBL, it is free and open to all users and there is no login requirement. | 2025