Summary
Publication

Title: Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimers disease

Authors: Shuo Chen, Yuzhou Chang, Liangping Li, Diana Acosta, Yang Li, Qi Guo, Cankun Wang, Emir Turkes, Cody Morrison, Dominic Julian, Mark E. Hester, Douglas W. Scharre, Chintda Santiskulvong, Sarah XueYing Song, Jasmine T. Plummer, Geidy E. Serrano, Thomas G. Beach, Karen E. Duff, Qin Ma & Hongjun Fu

Date published: 12/21/22

Date added: 6/1/23

Journal: Acta Neuropathologica Communications

DOI: 10.1186/s40478-022-01494-6

Protocol: 10x Genomics Visium

Data source: GSE220442

Study design

Species: human

Number of samples: 6

Region: Whole brain

Figure: Spatial transcriptomics (SRT) of the human middle temporal gyrus (MTG)..

Spot-level data

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Total spots in the plot: 582

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Gene expression

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Spatially variable genes

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Differential expression (DE) / Gene set enrichment

Sample:

Note: The MAST package were used to calculate DEGs on normalized gene expression data (parameter: log2FC > 0.25, adj.p-value < 0.05).

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0.5

Adjusted p-value cutoff:

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