Summary
Publication

Title: Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimers disease

Authors: Emilie L Castranio, Philip Hasel, Jean-Vianney Haure-Mirande, Angie V Ramirez Jimenez, B Wade Hamilton, Rachel D Kim, Charles G Glabe, Minghui Wang, Bin Zhang, Sam Gandy, Shane A Liddelow, Michelle E Ehrlich

Date published: 11/30/22

Date added: 6/1/23

Journal: Alzheimer's & Dementia

DOI: 10.1002/alz.12821

Protocol: 10x Genomics Visium

Data source: GSE203424

Study design

Species: mouse

Number of samples: 12

Region: Hippocampus

Figure: Inpp5d/SHIP1knockdown increased amyloid pathology and plaque-associated microglia number

Spot-level data

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Total spots in the plot: 582

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Gene expression

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Spatially variable genes

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Foldchange direction:
Differential expression (DE) / Gene set enrichment

Sample:

Note: The MAST package were used to calculate DEGs on normalized gene expression data (parameter: log2FC > 0.25, adj.p-value < 0.05).

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0.5

Adjusted p-value cutoff:

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DE direction:
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