Summary
Publication

Title: APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

Authors: Sangderk Lee, Nicholas A Devanney, Lesley R Golden, Cathryn T Smith, James L Schwartz, Adeline E Walsh, Harrison A Clarke, Danielle S Goulding, Elizabeth J Allenger, Gabriella Morillo-Segovia, Cassi M Friday, Amy A Gorman, Tara R Hawkinson, Steven M MacLean, Holden C Williams, Ramon C Sun, Josh M Morganti, Lance A Johnson

Date published: 3/28/23

Date added: 6/1/23

Journal: Cell Reports

DOI: 10.1016/j.celrep.2023.112196

Protocol: 10x Genomics Visium

Data source: GSE212323

Study design

Species: mouse

Number of samples: 6

Region: Whole brain

Figure: Graphical Abstract

Spot-level data

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Total spots in the plot: 582

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Gene expression

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Spatially variable genes

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Foldchange direction:
Differential expression (DE) / Gene set enrichment

Sample:

Note: The MAST package were used to calculate DEGs on normalized gene expression data (parameter: log2FC > 0.25, adj.p-value < 0.05).

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0.5

Adjusted p-value cutoff:

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DE direction:
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